SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferences

View all Images (6)

Cutaneous angioleiomyoma
Other Resources UpToDate PubMed

Cutaneous angioleiomyoma

Contributors: Catherine J. Wang, Susan Burgin MD
Other Resources UpToDate PubMed


Angioleiomyoma (AL) is a variant of leiomyoma that is characterized histopathologically by the presence of vascular channels as well as smooth muscle bundles. It is thought to arise from vascular smooth muscle cells. It typically presents as a single, slowly enlarging papule or nodule on the leg of a middle-aged woman. However, men are also affected and pediatric cases have been reported. ALs have been reported on the trunk, face, and upper extremities too.

While lower extremity ALs are reported to be painful, those that occur elsewhere on the body are usually asymptomatic. Pain may be spontaneous and paroxysmal or may be precipitated by light touch or pressure.


D21.9 – Benign neoplasm of connective and other soft tissue, unspecified

255188003 – Angiomyoma of skin

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

  • Angioleiomyolipoma – will see adipocytes on biopsy
  • Hemangioma
  • AIDS-associated Kaposi sarcoma
Differential diagnosis of painful benign tumors:
  • Angiolipoma
  • Blue rubber bleb nevus syndrome
  • Adiposis dolorosa
  • Cutaneous endometriosis
  • Glomus tumor
  • Cutaneous leiomyoma – usually multiple, may be agminated
  • Granular cell tumor
  • Solitary neurofibroma
  • Cutaneous neuroma

Best Tests

Subscription Required

Management Pearls

Subscription Required


Subscription Required


Subscription Required

Last Reviewed:10/10/2019
Last Updated:10/29/2019
Copyright © 2024 VisualDx®. All rights reserved.
Cutaneous angioleiomyoma
A medical illustration showing key findings of Cutaneous angioleiomyoma : Face, Trunk
Copyright © 2024 VisualDx®. All rights reserved.