Cutaneous epithelioid angiomatous nodule
Alerts and Notices
Synopsis
While some cases display cytologic atypia and mitoses histopathologically, CEAN is benign. Lesions tend to appear sporadically and do not favor any demographic over another, but adults are typically affected. No triggers for CEAN have been identified.
While some experts place CEANs in the spectrum of epithelioid hemangioma (EH, also known as angiolymphoid hyperplasia with eosinophilia), others view it as a distinct entity.
Codes
ICD10CM:L98.8 – Other specified disorders of the skin and subcutaneous tissue
SNOMEDCT:
817950008 – Cutaneous epithelioid angiomatoid nodule
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Pyogenic granuloma – Solitary, superficial polypoid lesion usually seen at sites of trauma, often on the head or distal extremities.
- Bacillary angiomatosis – History of associated immunocompromised condition (eg, AIDS) and prominent neutrophilia on lesion biopsy. Associated with demonstration of Bartonella henselae on Warthin-Starry staining.
- Kaposi sarcoma – History of associated immunocompromised condition (eg, AIDS) and prominent lymphocytic infiltrate on lesion biopsy. Associated with human herpesvirus-8 (HHV-8).
- Epithelioid angiosarcoma – Often deep vascular lesions with recurrent and aggressive behavior. Usually seen in elderly individuals. Cellular atypia, mitosis, and necrosis may be present on biopsy.
- Kimura disease – Similar to CEAN histopathologically but with more lymphoid aggregates.
- Epithelial hemangioendothelioma
- Sarcoid (see sarcoidosis)
- Lymphocytoma cutis
- Cutaneous metastases
- Cutaneous lymphoid hyperplasia
- Amelanotic melanoma
Best Tests
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Management Pearls
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Therapy
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References
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Last Reviewed:07/06/2021
Last Updated:07/26/2021
Last Updated:07/26/2021