Cutaneous eruption of lymphocyte recovery
Alerts and Notices
Synopsis
The pathophysiology of ELR is unclear, although it is postulated that it may be due to defective suppression of lymphocytes during rapid immunologic reconstitution or the preferential migration of T-lymphocytes to the skin to re-establish skin-associated lymphoid tissue.
Codes
ICD10CM:R21 – Rash and other nonspecific skin eruption
SNOMEDCT:
271807003 – Eruption of skin
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Acute graft-versus-host disease – Usually associated with gastrointestinal and hepatic abnormalities, and will progress without immunosuppressants.
- Exanthematous drug eruption (eg, antibiotics, nonsteroidal anti-inflammatory drugs [NSAIDs])
- DRESS
- Viral exanthem
- Engraftment syndrome – Typically occurs 7-14 days after chemotherapy. Associated with sustained fever and systemic signs of capillary leak syndrome.
- Urticaria
- Cellulitis
- Leukemia cutis
Best Tests
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:07/10/2017
Last Updated:07/27/2017
Last Updated:07/27/2017