Cutaneous eruption of lymphocyte recovery
The pathophysiology of ELR is unclear, although it is postulated that it may be due to defective suppression of lymphocytes during rapid immunologic reconstitution or the preferential migration of T-lymphocytes to the skin to re-establish skin-associated lymphoid tissue.
R21 – Rash and other nonspecific skin eruption
271807003 – Eruption of skin
Differential Diagnosis & Pitfalls
- Acute graft-versus-host disease – Usually associated with gastrointestinal and hepatic abnormalities, and will progress without immunosuppressants.
- Exanthematous drug eruption (eg, antibiotics, nonsteroidal anti-inflammatory drugs [NSAIDs])
- Viral exanthem
- Engraftment syndrome – Typically occurs 7-14 days after chemotherapy. Associated with sustained fever and systemic signs of capillary leak syndrome.
- Leukemia cutis
Drug Reaction Data