Cutaneous squamous cell carcinoma - Anogenital in
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Synopsis
The clinical presentation is variable. SCC often presents as a hyperkeratotic papule or nodule that may ulcerate, but it may also be smooth, plaque-like, exophytic, or papillomatous. Lesions are often red to skin colored. Secondary changes such as scale, crust, erosion, and ulceration can be present. The progression of lesions over time varies. Some enlarge slowly, while others progress rapidly to grow, infiltrate deeper tissue, and metastasize. Pain and tenderness can be present. Anal carcinomas may also present with rectal bleeding and a sensation of an object in the rectum.
The pathogenesis of SCC is multifactorial. It may evolve from intraepithelial neoplasia (including penile intraepithelial neoplasia or anal intraepithelial neoplasia) or arise de novo. TP53 and NOTCH1 gene mutations have been implicated. Penile SCC occurs almost exclusively in uncircumcised men, and neonatal circumcision is believed to be protective. Penile carcinoma is most often found on the glans (48%), followed by the foreskin (21%), corona (6%), and shaft (< 2%). It is believed that smegma, more commonly present in uncircumcised men, induces chronic inflammation and predisposes to SCC. Any repetitive trauma or insult increases risk of SCC. Additional risk factors for anogenital SCC include smoking, sexually transmitted infections, HIV infection, human papillomavirus (HPV) infection, poor genital hygiene, anogenital injury, chronic balanitis, lichen sclerosus, and erosive lichen planus. Approximately 50% of genital SCC cases are associated with HPV infection.
Men who engage in receptive anal intercourse and men with immunocompromised states such as HIV should undergo regular anal cytology testing.
Related topics: bowenoid papulosis, erythroplasia of Queyrat, squamous cell carcinoma in situ
Codes
ICD10CM:C44.92 – Squamous cell carcinoma of skin, unspecified
SNOMEDCT:
402815007 – Squamous cell carcinoma
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Differential Diagnosis & Pitfalls
- Bowen disease
- Basal cell carcinoma
- Verruca vulgaris
- Condyloma acuminatum
- Keratoacanthoma
- Eccrine poroma
- Lobular capillary hemangioma (pyogenic granuloma)
- Amelanotic melanoma
- Sporotrichosis
- Mycobacterium marinum infection
- Nummular dermatitis
- Irritated seborrheic keratosis
- Lichen planus
- Lichen sclerosus
- Granuloma inguinale
- Lymphogranuloma venereum
- Syphilis
- Prurigo nodularis
- Bowenoid papulosis
- Adnexal carcinomas
- Dermatofibrosarcoma protuberans
- Leiomyosarcoma
- Extramammary Paget disease
- Epithelioid sarcoma
- Psoriasis
- Lichen simplex chronicus
- Basosquamous carcinoma
- Pseudoepitheliomatous and micaceous balanitis – may evolve to SCC if untreated
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:02/21/2023
Last Updated:04/06/2023
Last Updated:04/06/2023
Patient Information for Cutaneous squamous cell carcinoma - Anogenital in
Overview
Squamous cell carcinoma (SCC) is the second most common form of skin cancer. Squamous cell carcinoma usually occurs on sun-damaged skin, especially in light-skinned individuals with a long history of chronic sun exposure.Squamous cell carcinoma requires treatment to prevent it from becoming too invasive. If it is caught early and treated appropriately, squamous cell carcinoma rarely spreads (metastasizes) to lymph nodes or to internal organs. However, if it is neglected, squamous cell carcinoma can cause tissue destruction or it may spread internally, causing serious health problems and even death.
Who’s At Risk
Although squamous cell carcinoma can be found worldwide, it is most commonly seen in elderly, light-skinned people with a large amount of sun exposure.Risk factors for the development of squamous cell carcinoma include:
- Age over 50 years
- light skin, light hair, or light eyes
- Male sex
- Chronic exposure to sunlight or other ultraviolet light
- Exposure to certain chemicals, such as arsenic or tar
- Exposure to radiation, such as X-ray treatment for internal cancers
- Long-term suppression of the immune system, such as organ transplant recipients
- Long-term presence of scars, such as from a gasoline burn
- Chronic ulcers
- Previous skin cancer
Signs & Symptoms
The most common locations for squamous cell carcinoma in light-skinned individuals include:- Head and neck
- Arms and hands
- Shoulders
- Back
- Lower lip, especially in smokers
- Legs
- Non-sun-exposed sites
- Sites of chronic scarring
- Non-healed leg ulcers
- Anus
Early squamous cell carcinomas do not typically have any symptoms, but larger lesions may be tender or may bleed.
Self-Care Guidelines
Preventing sun damage is crucial to avoiding the development of squamous cell carcinoma:- Avoid ultraviolet light exposure from natural sunlight or from artificial tanning devices.
- Wear broad-spectrum sunscreens (blocking both UVA and UVB) with SPF 30 or higher, reapplying frequently.
- Wear wide-brimmed hats and long-sleeved shirts.
- Stay out of the sun in the middle of the day (between 10:00 AM and 3:00 PM)
Once a month, you should perform a self-exam to look for signs of skin cancer. It is best to perform the exam in a well-lit area after a shower or bath. Use a full-length mirror with the added assistance of a hand mirror when necessary. Using a hair dryer can help you examine any areas of skin covered by hair, such as your scalp.
- In front of a full-length mirror, inspect the front of your body making sure to look at the front of your neck, chest (including under breasts), legs, and genitals.
- With your arms raised, inspect both sides of your body making sure to examine your underarms.
- With your elbows bent, examine the front and back of your arms as well as your elbows, hands, fingers, area between your fingers, and fingernails.
- Inspect the tops and bottoms of your feet, the area between your toes, and toenails.
- With your back to the mirror and holding a hand mirror, inspect the back of your body, including the back of your neck, shoulders, legs, and buttocks.
- Using a hand mirror, examine your scalp and face.
When to Seek Medical Care
If you have developed a new bump on sun-exposed skin, or if you have a spot that bleeds easily or does not seem to be healing, then you should make an appointment with your primary care physician or with a dermatologist. You should also make an appointment if an existing spot changes size, shape, color, or texture, or if it starts to itch, bleed, or become tender.Try to remember to tell your doctor when you first noticed the lesion and what symptoms, if any, it may have (such as easy bleeding or itching). Also be sure to ask your parents, siblings, and adult children whether or not they have ever been diagnosed with skin cancer, and relay this information to your physician.
Treatments
If your physician suspects squamous cell carcinoma, he or she will first want to establish the correct diagnosis by performing a biopsy of the lesion. The procedure involves:- Numbing the skin with an injectable anesthetic.
- Sampling a small piece of skin by using a flexible razor blade, a scalpel, or a tiny cookie cutter (called a "punch biopsy"). If a punch biopsy is taken, a suture (stitches) or two may be placed and will need to be removed 6-14 days later.
- Having the skin sample examined under the microscope by a specially trained physician (dermatopathologist).
- Cryosurgery with liquid nitrogen - Very cold liquid nitrogen is sprayed on the lesion, freezing it and destroying it in the process. This is a good option for low-risk squamous cell carcinomas.
- Electrodesiccation and curettage, also known as "scrape and burn" - After numbing the lesion, the doctor uses a curette to "scrape" the skin cancer cells away, followed by an electric needle to "burn," or cauterize, the tissue. The electrodesiccation helps to kill the cancer cells and also to staunch any bleeding of the site. This is a good option for low-risk squamous cell carcinomas.
- Excision - The squamous cell carcinoma is cut out with a scalpel, and stitches are usually placed to bring the wound edges together. This is a good option for low-risk and some high-risk squamous cell carcinomas.
- Mohs micrographic surgery - In this technique, the physician takes tiny slivers of skin from the cancer site until it is completely removed. This technique is particularly useful for high-risk squamous cell carcinomas and for lesions located on the nose, the ears, the lips, and the hands.
- Radiation treatment - X-ray therapy is often useful for patients who are not good surgical candidates because of other health issues.
Finally, it is important to remember that treatment of squamous cell carcinoma is not complete once the skin cancer has been removed. Frequent follow-up appointments with a dermatologist or with a physician trained to examine the skin are essential to ensure that the SCC has not recurred and that a new skin cancer has not developed. In addition, good sun protection habits (see Self-Care) are vital to preventing further ultraviolet light damage.
References
Bolognia, Jean L., ed. Dermatology, pp.1674-1693. New York: Mosby, 2003.
Freedberg, Irwin M., ed. Fitzpatrick's Dermatology in General Medicine. 6th ed. pp.737-743. New York: McGraw-Hill, 2003.
Cutaneous squamous cell carcinoma - Anogenital in
See also in: Overview,Hair and Scalp,Nail and Distal Digit