ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferencesView all Images (6)
Cytomegalovirus infection - Oral Mucosal Lesion
See also in: Overview,Anogenital
Print
Other Resources UpToDate PubMed

Cytomegalovirus infection - Oral Mucosal Lesion

See also in: Overview,Anogenital
Print Images (6)
Contributors: Zamambo Mkhize MBChB, FCDerm, Anisa Mosam MBChB, MMed, FCDerm, PhD, Paritosh Prasad MD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Cytomegalovirus (CMV) is an opportunistic pathogen in immunocompromised patients, especially in human immunodeficiency virus (HIV) and solid-organ transplant patients. Cases have also been described in patients with collagen vascular disease or lymphoma and patients on chronic corticosteroids.

Involvement of the oral cavity is rare, ulcers being the most frequent manifestation of CMV infection of the gastrointestinal tract. Infrequently, CMV can cause periodontitis, gingival hyperplasia, and sialadenitis in the oral cavity.

Patients often have concomitant infection of the gastrointestinal tract (bloody diarrhea) and/or the eyes (chorioretinitis). Other symptoms include lymphadenopathy, hepatosplenomegaly, esophagitis, pneumonia, and meningoencephalitis. Transmission is by body secretions, including saliva, blood, urine, breast milk, semen, and cervical fluid.

In one case report, an immunocompromised patient had an oral ulcer that was simultaneously infected by CMV, herpes simplex virus, and Epstein-Barr virus. The pathogenesis of coinfected ulcers is unknown, but it is thought that these human herpesviruses may potentiate each other.

With the advent of antiretroviral therapy (ART), this oral infection has been on the decline in the United States.

Related topic: Cytomegalovirus infection of newborn, Cytomegalovirus retinitis

Codes

ICD10CM:
B25.9 – Cytomegaloviral disease, unspecified

SNOMEDCT:
28944009 – Cytomegalovirus infection

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required

References

Subscription Required

Last Reviewed: 03/29/2019
Last Updated: 05/24/2019
Copyright © 2019 VisualDx®. All rights reserved.
Cytomegalovirus infection - Oral Mucosal Lesion
See also in: Overview,Anogenital
Print 6 Images
View all Images (6)
(with subscription)
Cytomegalovirus infection (Systemic Symptoms) : Fever, Rash, ALT elevated, AST elevated, Lymphadenopathy, Malaise, Myalgia, Pharyngitis, LYP increased, MON increased
Clinical image of Cytomegalovirus infection
Copyright © 2019 VisualDx®. All rights reserved.