Dermatofibroma in Adult
Histologically, dermatofibromas represent a well-circumscribed proliferation of fibrohistiocytic spindle-shaped cells interspersed among thickened dermal collagen bundles. The epidermis may show some acanthosis with basal layer hyperpigmentation. Immunohistochemistry typically reveals positive staining with factor XIIIA.
Dermatofibromas are often solitary, though any individual may have more than one. Rarely, multiple eruptive dermatofibromas (MEDF) may occur in patients. MEDF is arbitrarily defined as the presence of a minimum of anywhere from 5 to 15 or more dermatofibromas developing in less than a 4-month period. MEDF has been reported to occur in the setting of human immunodeficiency virus (HIV) infection; autoimmune disease, most frequently systemic lupus erythematosus; and neoplastic disease. Multiple clustered dermatofibroma (MCDF) is an entity where 15 or more dermatofibromas cluster together to form a plaque, most often on the lower half of the body in the first to third decades.
In rare families with dominantly inherited dermatofibroma, missense mutation in the factor XIII A-subunit has been detected.
D23.9 – Other benign neoplasm of skin, unspecified
427186000 – Dermatofibroma
- Melanocytic nevus
- Blue nevus
- Dysplastic nevus
- Prurigo nodularis
- Lichenoid keratosis
- Basal cell carcinoma
- Inflamed seborrheic keratosis
- Squamous cell carcinoma
- Dermatofibrosarcoma protuberans (DFSP) is a locally invasive malignant neoplasm that can begin as a dermatofibroma-size lesion. DFSP favors the trunk and progressively increases in size, while dermatofibromas do not substantially increase in size and favor the extremities.
- Spitz nevus
- Keloid or hypertrophic scar (see scar)
- Atypical fibroxanthoma
- Neurilemmoma (schwannoma)
- Foreign body granuloma