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Dermatofibroma in Adult
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Dermatofibroma in Adult

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Contributors: Cynthia Marie Carver DeKlotz MD, Belinda Tan MD, PhD, Sarah Hocker DO, Lowell A. Goldsmith MD, MPH
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Synopsis

Dermatofibromas, or histiocytomas, are common, benign skin neoplasms composed of collagen, macrophages (histiocytes), capillaries, and fibroblasts. The etiology and pathogenesis are unknown, though some may arise at sites of trauma or insect bites. They are firm, skin-colored or slightly pigmented papules or nodules. They may be tender or pruritic, and they often persist for life. They are most common on the legs of women and usually appear in young adulthood. They may heal as depressed scars after several years.

Histologically, dermatofibromas represent a well-circumscribed proliferation of fibrohistiocytic spindle-shaped cells interspersed among thickened dermal collagen bundles. The epidermis may show some acanthosis with basal layer hyperpigmentation. Immunohistochemistry typically reveals positive staining with factor XIIIa.

Dermatofibromas are often solitary, though any individual may have more than one. Rarely, multiple eruptive dermatofibromas (MEDF) may occur in patients. MEDF is arbitrarily defined as the presence of a minimum of anywhere from 5 to 15 or more dermatofibromas developing in less than a 4-month period. MEDF has been reported to occur in the setting of human immunodeficiency virus (HIV) infection; autoimmune disease, most frequently systemic lupus erythematosus; and neoplastic disease. Multiple clustered dermatofibroma (MCDF) is an entity where 15 or more dermatofibromas cluster together to form a plaque, most often on the lower half of the body in the first to third decades.

Codes

ICD10CM:
D23.9 – Other benign neoplasm of skin, unspecified

SNOMEDCT:
427186000 – Dermatofibroma

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Last Updated: 10/09/2018
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Dermatofibroma in Adult
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Dermatofibroma : Leg, Smooth nodule, Smooth papule
Clinical image of Dermatofibroma
A close-up of a violaceous papule with a light brown rim.
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