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Diffuse large B-cell lymphoma
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Diffuse large B-cell lymphoma

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Contributors: Nina Haghi MD, Paritosh Prasad MD
Other Resources UpToDate PubMed

Synopsis

Diffuse large B-cell lymphoma (DLBCL) is a mature neoplasm of large B-lymphoid cells and is the most common subtype of non-Hodgkin lymphoma (it constitutes 25%-35% of adult non-Hodgkin lymphomas).

DLBCL is more frequent in elderly individuals (median age is 64 years) and shows a slightly male predominance. There are many subtypes of DLBCL characterized by distinct morphologies, locations, and/or molecular signatures. A very rare subtype of large B-cell lymphoma is intravascular B-cell lymphoma, which is often difficult to diagnosis due to vague nonspecific symptoms and is usually aggressive.

Patients may present with nodal or extranodal disease (the most common extranodal site is the gastrointestinal tract) or a mass that is rapidly enlarging. B symptoms (fever, weight loss, night sweats) are present, but asymptomatic presentations can also occur.

Codes

ICD10CM:
C83.30 – Diffuse large B-cell lymphoma, unspecified site

SNOMEDCT:
109969005 – Diffuse non-Hodgkin's lymphoma, large cell

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 08/03/2018
Last Updated: 09/11/2018
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Diffuse large B-cell lymphoma
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Diffuse large B-cell lymphoma : Fatigue, Fever, Night sweats, Lymphadenopathy, Weight loss
Copyright © 2019 VisualDx®. All rights reserved.