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Diffuse neonatal hemangiomatosis
Other Resources UpToDate PubMed

Diffuse neonatal hemangiomatosis

Contributors: Craig N. Burkhart MD, Dean Morrell MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed

Synopsis

Diffuse neonatal hemangiomatosis is characterized by multiple hemangiomatous lesions present at birth or that develop rapidly within the first few days of life. In diffuse neonatal hemangiomatosis, multiple cutaneous and visceral hemangiomas can lead to life-threatening complications. Potential involved organs include the gastrointestinal (GI) tract (leading to GI bleeding), larynx, lungs, central nervous system, spleen, and liver. Arteriovenous (AV) shunts and hepatic involvement can lead to high-output cardiac failure and death. Mortality is estimated to be over 50%. Cerebral hemorrhage is another cause of death. Infants presenting with multiple disseminated hemangiomas need to be evaluated and managed aggressively.

Codes

ICD10CM:
D18.01 – Hemangioma of skin and subcutaneous tissue

SNOMEDCT:
254782003 – Multiple progressive hemangiomata

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Benign neonatal hemangiomatosis has similar cutaneous lesions, but unlike diffuse neonatal hemangiomatosis, there is no visceral involvement, with skin lesions quickly and spontaneously resolving.
  • Cytomegalovirus infection of newborn
  • Congenital leukemia
  • Congenital rubella

Best Tests

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Management Pearls

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Therapy

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References

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Last Updated:02/01/2022
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Diffuse neonatal hemangiomatosis
A medical illustration showing key findings of Diffuse neonatal hemangiomatosis : Failure to thrive, Scattered many, Vascular plaque, Widespread distribution, Friable papules, Red
Clinical image of Diffuse neonatal hemangiomatosis - imageId=1707372. Click to open in gallery.  caption: 'Multiple red and violaceous papules and nodules on the back, buttocks, and thigh. Note also the unrelated gray patches of congenital dermal melanocytosis on the buttocks.'
Multiple red and violaceous papules and nodules on the back, buttocks, and thigh. Note also the unrelated gray patches of congenital dermal melanocytosis on the buttocks.
Copyright © 2024 VisualDx®. All rights reserved.