DCM may have an ischemic or nonischemic etiology. Nonischemic causes include inherited muscular disease, chemotherapy (eg, anthracyclines), endocrinopathies (eg, thyrotoxicosis, pheochromocytoma), infiltrative diseases (eg, amyloidosis), alcohol use disorder, and viral myocarditis. Genetic causes include mutations in genes encoding cardiac sarcomere and cytoskeletal proteins. Many cases are idiopathic.
Patients usually present with symptoms of heart failure including dyspnea, edema, orthopnea, and weight gain. Physical examination may reveal signs of acute left ventricular failure, such as S3 gallop, systolic murmur consistent with mitral regurgitation, pleural effusions, jugular venous distension, and/or peripheral edema.
I42.0 – Dilated cardiomyopathy
399020009 – Congestive cardiomyopathy
Differential Diagnosis & Pitfalls
Drug Reaction Data