Disseminated Fusarium infection in Adult
Localized fusariosis presents as white superficial onychomycosis, intertrigo, tinea pedis, or cellulitis.
In disseminated fusariosis, the infection involves 2 or more noncontiguous sites, including the skin, lungs, eye, or other organs. The portal of entry may be the skin (in around a third of patients) especially via an indwelling venous catheter, or the respiratory or gastrointestinal (GI) tracts. There is often an abrupt onset of fever that can exceed 40°C (104°F) with malaise, chills, and myalgias. Skin lesions spread rapidly, involving the trunk and extremities. Sinopulmonary infection may also occur. Typically, patients have hematologic malignancies and immunosuppression, and Fusarium infection often follows bone marrow transplants. Only a few of all known cases involved patients who were not profoundly immunosuppressed. Chronic granulomatous disease can also predispose to Fusarium infection. The onset of disseminated Fusarium infection is generally a terminal event, with death occurring in 73% of reported cases.
Related topic: Fungal Corneal Ulcer
B48.8 – Other specified mycoses
64250002 – Fusarium infection
Differential Diagnosis & Pitfalls
- Candida sepsis
- Mycobacterium avium-intracellulare complex
- Atypical mycobacterial infections
- Ecthyma gangrenosum due to Pseudomonas
- Erythema nodosum
- Pyoderma gangrenosum
- Ecthyma due to streptococci
- Ecthyma gangrenosum-like lesions due to other bacteria (Aeromonas, Citrobacter, Escherichia coli, Klebsiella, Morganella, Serratia, Staphylococcus, Vibrio) or fungi (Aspergillus, Candida, Exserohilum, Metarhizium, Mucor, Scytalidium)