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Drug-induced pigmentation in Child
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Drug-induced pigmentation in Child

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Contributors: William Schaffenburg MD, Susan Burgin MD
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Synopsis

Drug-induced pigmentation or dyspigmentation represents 10%-20% of all cases of acquired hyperpigmentation. Mechanisms of drug-induced pigmentation include cutaneous deposition of the drug or its metabolites, accumulation of melanin, deposition of iron, or synthesis and deposition of special pigments such as lipofuscin. Increased melanin produces brown pigmentation. When medications are deposited in the dermis, they can cause blue-black or muddy-brown macules. Drugs commonly associated with hyperpigmentation include NSAIDs, antimalarials, psychotropic medications, amiodarone, bleomycin, tetracyclines (most commonly minocycline), chemotherapeutic agents, and metals such as silver and gold.

Related topics: Drug-Induced Flagellate Pigmentation, Amiodarone Drug-Induced Pigmentation, Minocycline Drug-Induced Pigmentation, Drug-Induced Hypopigmentation, Drug-Induced Oral Pigmentation, Drug-Induced Nail Pigment

Codes

ICD10CM:
T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter

SNOMEDCT:
110284009 – Drug-induced pigmentation

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 10/28/2016
Last Updated: 01/09/2017
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Drug-induced pigmentation in Child
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Drug-induced pigmentation : Black color, Blue color, Brown color, Green color, Hyperpigmented patches
Clinical image of Drug-induced pigmentation
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