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Drug-induced anorexia
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Drug-induced anorexia

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Contributors: Michael W. Winter MD, Paritosh Prasad MD
Other Resources UpToDate PubMed

Synopsis

Drug-induced anorexia is an abnormal loss of appetite associated with the use of a medication or other drug. It may be associated with drug-induced nausea or vomiting. Many medications have been associated with drug-induced anorexia (see Drug Reaction Data below).

Possible mechanisms include inhibited reuptake of dopamine and serotonin, increase of hypothalamic neurotransmitters, disruption of the endogenous digoxin-like factor, and early satiety caused by abnormal serum leptin concentrations. Patients may complain of dysgeusia, dysphagia, weight loss, fatigue, and xerostomia. The elderly, patients with depression, and patients with dementia are at increased risk.

Drug-induced anorexia can subsequently lead to weight loss, malaise, nutritional deficiencies, and, in severe cases, dehydration with hypoperfusion and end-organ damage or electrolyte imbalances complicated by cardiac dysrhythmias.

Codes

ICD10CM:
R63.0 – Anorexia

SNOMEDCT:
79890006 – Loss of appetite

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 01/02/2018
Last Updated: 06/15/2018
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Drug-induced anorexia
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Drug-induced anorexia : Weight loss, Anorexia
Copyright © 2019 VisualDx®. All rights reserved.