The most common class of medications causing cough is the angiotensin converting enzyme (ACE) inhibitors, which decrease bradykinin metabolism and are thought to cause 75% of cases of drug-induced cough.
Other medications induce cough by provoking bronchospasm (including beta blockers, NSAIDs, and aspirin-containing products) or by worsening gastroesophageal or laryngopharyngeal reflux (including bisphosphonates, calcium antagonists, and systemic steroids).
Other mechanisms of drug-induced cough are idiopathic and/or can herald the onset of interstitial lung disease or other disorders.
J70.4 – Drug-induced interstitial lung disorders, unspecified
196051003 – Drug-induced interstitial lung disorders
Differential Diagnosis & Pitfalls
Drug Reaction Data