Drug-induced dyspnea

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Synopsis

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Difficult breathing, also called shortness of breath, characterized by tightness of the chest, distressed feeling of not being able to get adequate breath, and uncomfortable or painful inhalation ranging from mild to a sense of suffocation. Medications that can precipitate respiratory impairment include ACE inhibitors, NSAIDs, anticonvulsants, beta blockers, calcium channel blockers, cholinergics, antihypertensives, antibiotics, antifungals, antimicrobials, antiretrovirals, digoxin, interferon, and chemotherapy agents. Also caused by substances such as cocaine, codeine, heroin, methadone, and propoxyphene.

Management may include re-evaluation of medication / dosage / interactions and careful monitoring during medication changes. In the event that medications causing dyspnea are unavoidable, such as in pain management and palliative care, additional support services can be provided. This includes supplemental oxygen, respiratory therapy, and pulmonary rehabilitation.

Codes

ICD10CM:
T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter

SNOMEDCT:
267036007 – Dyspnea

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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