Persistent inability to achieve and maintain penile erection during sexual activity. May be associated with other mechanisms of sexual dysfunction such as decreased libido and abnormal ejaculation. Erectile dysfunction is known to increase with age and comorbidities, and in older men there is a greater likelihood of medications that may contribute to erectile dysfunction. Associated medications include antihistamines, antihypertensives, antidepressants, antipsychotics, antiretroviral agents, opiates, histamine H2-receptor antagonists (H2-blockers), antiandrogens, and thiazide diuretics. Use of recreational drugs, excessive alcohol consumption, and smoking can contribute to erective dysfunction.

Management involves weighing the benefits of medications against the adverse effects. Medication dosage may be adjusted, or alternate treatments may be sought depending on the patient's condition and preferences.

Related topic: Substance-Induced Sexual Dysfunction