ContentsSynopsisCodesDrug Reaction Data
Drug-induced fatigue
Other Resources UpToDate PubMed

Drug-induced fatigue

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Other Resources UpToDate PubMed


Lethargy, weariness, and sense of near exhaustion following the use of certain medications. Commonly associated with antidepressants, anxiolytics, antihistamines, antihypertensive agents, alpha-receptor agonists, beta blockers, chemotherapy drugs, sedatives, hypnotics, narcotics, and other drugs.

Management involves balancing the patient's need for and tolerance of prescribed medication to treat a medical condition against the risk of adverse effects.


T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter

84229001 – Fatigue

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Updated: 11/17/2016
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Drug-induced fatigue
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Drug-induced fatigue : Fatigue
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