SynopsisCodesDifferential Diagnosis & PitfallsBest TestsDrug Reaction Data
Emergency: requires immediate attention
Drug-induced heart failure
Other Resources UpToDate PubMed
Emergency: requires immediate attention

Drug-induced heart failure

Contributors: Ryan Hoefen MD, PhD
Other Resources UpToDate PubMed


The inability of the heart to pump blood effectively, caused by an adverse reaction to a drug. A variety of drug agents have been associated with drug-induced heart failure. Some common noncardiac drugs include (but are not limited to) cocaine, tyrosine kinase inhibitors and other chemotherapeutic agents, beta blockers, NSAIDs, anesthetics, and/or antidepressants. Patients may present with dyspnea on exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, and pulmonary edema on physical exam or chest x-ray. Patients receiving drugs associated with drug-induced heart failure should be monitored closely for cardiovascular effects.


I50.9 – Heart failure, unspecified

622199016 – Drug-induced pulmonary hypertension

Differential Diagnosis & Pitfalls

  • Pneumonia (Viral pneumonia, Streptococcus pneumoniae pneumonia)
  • Chronic obstructive pulmonary disease
  • Bronchitis (Acute bronchitis, Chronic bronchitis)
  • Myxedema
  • Acute kidney injury
  • Acute respiratory distress syndrome
  • Congestive hepatopathy
  • Antiglomerular basement membrane disease
  • Pulmonary fibrosis
  • Acute coronary syndrome
  • Pulmonary embolism
  • Acute Acute coronary syndrome
  • Dilated cardiomyopathy
  • Hypertrophic cardiomyopathy
  • Valvular heart failure
  • Atrial septal defect
  • Ventricular septal defect
  • Constrictive pericarditis
  • Pulmonary hypertension

Best Tests

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Updated:01/30/2017
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Emergency: requires immediate attention
Drug-induced heart failure
A medical illustration showing key findings of Drug-induced heart failure : Chest pain, Fatigue, Peripheral leg edema, Dyspnea, Generalized weakness
Copyright © 2024 VisualDx®. All rights reserved.