Drug-induced hemoptysis
Alerts and Notices
Synopsis

Although only 1% of the pulmonary blood supply typically comes from bronchial arteries, approximately 90% of hemoptysis cases are bronchial in origin. Patients with chronic inflammation (eg, cystic fibrosis), thrombosis or thromboembolism, vasculitis, lung neoplasms, or any etiology that impairs pulmonary arteries tend to produce more bronchial arteries. Because bronchial arteries are structurally more fragile than pulmonary arteries, they rupture more easily with increased pressure from coughing, resulting in hemoptysis. In many cases, it is patients with these predispositions who are more likely to develop hemoptysis with the initiation of certain drugs, but patients may also develop drug-induced hemoptysis even without any risk factors. Hemoptysis of any etiology is significantly more common in the adult population. The classic patient is around 60 years of age and male.
The treatment for mild hemoptysis is predominantly supportive, involving oxygenation, suction, and occasionally transfusion. In cases of massive hemoptysis, where patients may expectorate ≥ 500 cc of blood in 24 hours or > 100 cc an hour, bronchoscopy may be indicated for invasive treatment.
Codes
ICD10CM:R04.2 – Hemoptysis
SNOMEDCT:
66857006 – Hemoptysis
Look For
Subscription Required
Diagnostic Pearls
Subscription Required
Differential Diagnosis & Pitfalls
- Arteriovenous malformation
- Aortobronchial fistula
- Pulmonary embolism
- Tuberculosis
- Aspergillosis
- Vasculitis / collagen vascular disease
- Bleeding disorder (eg, von Willebrand disease, hemophilia, platelet disorders)
- Malignancy (particularly lung, oropharyngeal, metastasis to lung)
- Mitral stenosis
- Upper gastrointestinal bleeding
- Upper respiratory bleeding
Best Tests
Subscription Required
Management Pearls
Subscription Required
Therapy
Subscription Required
Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
Subscription Required
Last Reviewed:07/25/2019
Last Updated:07/29/2019
Last Updated:07/29/2019