ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferencesView all Images (29)
Eccrine poroma
Print Captions OFF
Other Resources UpToDate PubMed

Eccrine poroma

Print Images (29)
Contributors: Amy Kalowitz Bieber MD, Amanda Robinson MD, Alexa Kimball MD, Belinda Tan MD, PhD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed

Synopsis

A poroma is a relatively rare benign adnexal neoplasm that originates from the intra-epidermal portion of the sweat gland duct (the acrosyringium). It is thought to arise from the eccrine sweat gland, but apocrine features may be seen. Eccrine poroma falls into the broader category of poroid neoplasms, or acrospiromas, which also includes the apocrine poroma, hidroacanthoma simplex, dermal duct tumor, and nodular, clear cell, and poroid hidradenomas.

Eccrine poromas occur only in the skin and most often present as a solitary, skin-colored or slightly erythematous, smooth or verrucous papule. They are less commonly pigmented or pedunculated. Poromas are usually less than 2 cm in diameter and are slow growing or fixed in size. Ulceration may occur, especially when over pressure points. Extremities, specifically palms and soles, are the most common sites, but they can occur anywhere; cases have been reported on the trunk, face, and neck. Rarely, patients may develop multiple poromas, or eccrine poromatosis. This condition is characterized by varying numbers of papules, more than 100 in some cases, that may be distributed widely or confined to the palms and soles.

Sweat gland tumors are thought to represent as little as 1% of primary cutaneous lesions, and poromas comprise only 10% of these. Poromas generally occur in adults over the age of 40, with no predilection for sex or ethnicity, and there is no apparent familial component. No definitive pathogenesis has been described, but cases have been reported as occurring in association with radiation exposure, trauma, pregnancy, hypohidrotic ectodermal dysplasia, and Bowen disease. They may also develop secondarily within a nevus sebaceus. Eccrine poromatosis has been reported in patients with lymphoproliferative disorders that have been treated with chemotherapy. Onset has varied from during the chemotherapy until years after.

Rarely, malignant eccrine poroma, or porocarcinoma, develops, either de novo or by transformation within a benign eccrine poroma. These lesions have metastatic potential.

Codes

ICD10CM:
D23.9 – Other benign neoplasm of skin, unspecified

SNOMEDCT:
399985004 – Eccrine poroma

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

The histology of eccrine poromas is similar to that of hidradenoma, acrospiroma, and poroid hidradenoma.

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required

References

Subscription Required

Last Reviewed: 08/12/2019
Last Updated: 08/29/2019
Copyright © 2019 VisualDx®. All rights reserved.
Eccrine poroma
Captions OFF Print 29 Images Filter Images
View all Images (29)
(with subscription)
 Reset
Eccrine poroma : Palm, Smooth nodule, Smooth papule, Plantar foot, Single skin lesion
Clinical image of Eccrine poroma
A close-up of a smooth, deep pink papule.
Copyright © 2019 VisualDx®. All rights reserved.