Eosinophilic esophagitis
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Synopsis

Eosinophilic esophagitis (EoE) is a chronic immune- or antigen-mediated disease characterized by typical symptoms of gastroesophageal reflux disease (GERD), with esophageal mucosal biopsies demonstrating squamous epithelium with eosinophil-predominant inflammation. EoE is a relatively newly described disease entity, recognized because of large subsets of children, adolescents, and young adults with continued reflux that is nonresponsive to acid-suppressive medication. Estimated prevalence of EoE is 0.4% in adult and pediatric populations in the Western world.
Clinical manifestations vary by age, with children presenting with feeding difficulties and abdominal pain and adolescents and adults typically presenting with dysphagia and food impaction. EoE should be considered in adults with GERD not responsive to proton pump inhibitor therapy or with atypical chest pain. Important risk factors for development of EoE include food allergies, environmental allergies, asthma, atopic dermatitis, and family history of EoE. EoE should be considered in patients presenting with food impactions of unclear etiology.
Related topics: eosinophilic gastroenteritis, esophageal stricture
Clinical manifestations vary by age, with children presenting with feeding difficulties and abdominal pain and adolescents and adults typically presenting with dysphagia and food impaction. EoE should be considered in adults with GERD not responsive to proton pump inhibitor therapy or with atypical chest pain. Important risk factors for development of EoE include food allergies, environmental allergies, asthma, atopic dermatitis, and family history of EoE. EoE should be considered in patients presenting with food impactions of unclear etiology.
Related topics: eosinophilic gastroenteritis, esophageal stricture
Codes
ICD10CM:
K20.0 – Eosinophilic esophagitis
SNOMEDCT:
235599003 – Eosinophilic Esophagitis
K20.0 – Eosinophilic esophagitis
SNOMEDCT:
235599003 – Eosinophilic Esophagitis
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Gastroesophageal reflux esophagitis
- Infectious esophagitis – viral, fungal, parasitic (rare)
- Pericarditis
- Esophageal foreign body
- Esophageal stricture, web, ring
- Functional dyspepsia
- Nonulcer reflux disease
- Helicobacter pylori gastritis
- Peptic ulcer disease
- Inflammatory bowel disease – Crohn disease, esophageal (rare)
- Achalasia (see esophageal motility disorder)
Best Tests
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Management Pearls
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Therapy
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References
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Last Reviewed:11/07/2016
Last Updated:06/07/2022
Last Updated:06/07/2022