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Eosinophilic esophagitis
Other Resources UpToDate PubMed

Eosinophilic esophagitis

Contributors: Michael W. Winter MD, Christine Osborne MD, Khaled Bittar MD, Nishant H. Patel MD, Desiree Rivera-Nieves MD
Other Resources UpToDate PubMed


Eosinophilic esophagitis (EoE) is a chronic immune- or antigen-mediated disease characterized by typical symptoms of gastroesophageal reflux disease (GERD), with esophageal mucosal biopsies demonstrating squamous epithelium with eosinophil-predominant inflammation. EoE is a relatively newly described disease entity, recognized because of large subsets of children, adolescents, and young adults with continued reflux that is nonresponsive to acid-suppressive medication. Estimated prevalence of EoE is 0.4% in adult and pediatric populations in the Western world.

Clinical manifestations vary by age, with children presenting with feeding difficulties and abdominal pain and adolescents and adults typically presenting with dysphagia and food impaction. EoE should be considered in adults with GERD not responsive to proton pump inhibitor therapy or with atypical chest pain. Important risk factors for development of EoE include food allergies, environmental allergies, asthma, atopic dermatitis, and family history of EoE. EoE should be considered in patients presenting with food impactions of unclear etiology.

Related topics: eosinophilic gastroenteritis, esophageal stricture


K20.0 – Eosinophilic esophagitis

235599003 – Eosinophilic Esophagitis

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Differential Diagnosis & Pitfalls

  • Gastroesophageal reflux disease
  • Infectious Esophagitis – viral, fungal, parasitic (rare)
  • Pericarditis
  • Esophageal foreign body
  • Esophageal stricture, Esophageal web, Schatzki ring
  • Functional dyspepsia
  • Nonulcer reflux disease
  • Helicobacter pylori infection
  • Peptic ulcer disease
  • Inflammatory bowel disease – Crohn disease, esophageal (rare)
  • Achalasia (see Esophageal motility disorder)

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Last Reviewed:11/07/2016
Last Updated:06/07/2022
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Eosinophilic esophagitis
A medical illustration showing key findings of Eosinophilic esophagitis (Adult) : Chest pain, Nausea, IgE elevated, Upper abdominal pain, Dysphagia, Dyspepsia, Regurgitation, EOS increased
Copyright © 2024 VisualDx®. All rights reserved.