Eosinophilic fasciitis in Child
EF presents with symmetric tenderness, erythema, and edema of affected extremities, with induration of the underlying muscle fascia and subcutaneous tissue occurring over days to weeks. The skin becomes tethered, giving rise to a characteristic dimpling and peau d'orange appearance. Elevation of the affected limb will cause a depression along superficial veins, leading to distinctive furrowing referred to as the groove sign. Constitutional symptoms, such as fatigue and weight loss, and local hypopigmentation, hair loss, and scaling may be seen. Secondary arthritis, joint contractures, and nerve compression may occur. Arthritis is less commonly seen among children than adults.
The disease is typically symmetric and preferentially affects the extremities, especially the forearms and calves. The face is generally spared. The hands and feet are affected more frequently in children than adults.
A unique variant has been described in children, in which patients present with painless contractures and a biopsy diagnostic of EF without the typical progression of swelling, pain, and characteristic dermatologic findings. Plaque morphea has been seen to present concurrently with EF.
M35.4 – Diffuse (eosinophilic) fasciitis
24129002 – Fasciitis with eosinophilia syndrome
Differential Diagnosis & Pitfalls
Drug Reaction Data