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Eosinophilic gastroenteritis
Other Resources UpToDate PubMed

Eosinophilic gastroenteritis

Contributors: Michael W. Winter MD, Paritosh Prasad MD
Other Resources UpToDate PubMed


Eosinophilic gastroenteritis (EGE) is defined by eosinophilic infiltration of the mucosa, muscular layer, or subserosal tissue of any segment of the gastrointestinal (GI) tract from the mouth to anus in the absence of another explanation for the eosinophilia. Most commonly, EGE is distributed in the stomach and small intestine. It is a rare and chronic GI disorder with no known etiology that can present at any age, but is most often diagnosed between the third and fifth decades of life. Approximately half of patients have a personal or family history of atopy defined as food sensitivities, eczema, or rhinitis.

EGE presents with nonspecific symptomatology and is a difficult diagnosis to distinguish from other causes of GI inflammation or malabsorption. The symptom profile varies depending on the depth of eosinophil infiltration:
  • Mucosal disease (most common) – Abdominal pain, nausea, diarrhea, vomiting. Malabsorption with micronutrient deficiency, anemia, and protein-losing enteropathy.
  • Muscular layer infiltration – Bowel obstruction due to intestinal wall thickening.
  • Subserosal disease (least common) – Ascites not explained by another mechanism and symptoms of mucosal and muscular layer disease.
Related topic: eosinophilic esophagitis


K52.81 – Eosinophilic gastritis or gastroenteritis

359804008 – Eosinophilic Gastroenteritis

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Polyarteritis nodosa
  • Inflammatory bowel disease (ie, Crohn disease or Ulcerative colitis)
  • Intestinal lymphoma
  • Hypereosinophilic syndrome
  • Gastric cancer
  • Eosinophilic granuloma
  • Chronic causes of Gastroenteritis (parasitic, bacterial, Viral gastroenteritis)
  • Milk protein sensitivity
  • Helicobacter pylori infection
  • Drug-induced Gastritis, duodenitis, or jejunitis
  • Eosinophilic granulomatosis with polyangiitis
  • Celiac disease

Best Tests

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Management Pearls

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Reviewed:12/13/2017
Last Updated:07/23/2023
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Eosinophilic gastroenteritis
A medical illustration showing key findings of Eosinophilic gastroenteritis : Abdominal pain, Diarrhea, Nausea/vomiting, Abdominal distension, Hypoalbuminemia, Anorexia, EOS increased
Copyright © 2024 VisualDx®. All rights reserved.