EGE presents with nonspecific symptomatology and is a difficult diagnosis to distinguish from other causes of GI inflammation or malabsorption. The symptom profile varies depending on the depth of eosinophil infiltration:
- Mucosal disease (most common) – Abdominal pain, nausea, diarrhea, vomiting. Malabsorption with micronutrient deficiency, anemia, and protein-losing enteropathy.
- Muscular layer infiltration – Bowel obstruction due to intestinal wall thickening.
- Subserosal disease (least common) – Ascites not explained by another mechanism and symptoms of mucosal and muscular layer disease.
K52.81 – Eosinophilic gastritis or gastroenteritis
359804008 – Eosinophilic Gastroenteritis
- Polyarteritis nodosa
- Inflammatory bowel disease (ie, Crohn disease or ulcerative colitis)
- Intestinal lymphoma
- Idiopathic hypereosinophilic syndrome
- Gastric cancer
- Eosinophilic granuloma
- Chronic causes of infectious gastroenteritis (parasitic, bacterial, viral)
- Milk protein sensitivity
- Helicobacter pylori infection
- Drug-induced gastritis, duodenitis, or jejunitis
- Eosinophilic granulomatosis with polyangiitis
- Celiac disease