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Eosinophilic granuloma in Child
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Eosinophilic granuloma in Child

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Contributors: Benjamin L. Mazer MD, MBA, David Sullo MD
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Synopsis

An idiopathic variation of Langerhans cell histiocytosis, commonly seen as a non-neoplastic osteolytic lesion of bone. Lesions can be unifocal or multifocal. The disease also presents as chronic inflammation in the soft tissue and can result in painless nodules around the head and neck. Lymphadenopathy is common as are fever, eosinophilia, and bone pain. The skin, lungs, eyes, brain, liver, gastrointestinal tract, and bone marrow may also become involved. Seen in adults, but occurs most often in children and twice as frequently in males. Lesions characteristically contain Langerhans cells with histiocytes, neutrophils, eosinophils, and lymphocytes. Treatments include surgery and chemotherapy.

Codes

ICD10CM:
C96.6 – Unifocal Langerhans-cell histiocytosis

SNOMEDCT:
370610003 – Non-neoplastic eosinophilic granuloma

Differential Diagnosis & Pitfalls

Pulmonary:
Bone:

Best Tests

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References

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Last Updated: 08/12/2016
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Eosinophilic granuloma in Child
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Eosinophilic granuloma : Fever, Bone pain, Malaise, WBC elevated, EOS increased
Imaging Studies image of Eosinophilic granuloma
Axial CT of the pelvis demonstrates a large lytic lesion involving the right hip with cortical destruction. This pediatric patient also had multiple other sites of lytic lesions, including the skull. Given the constellation of findings, this is most compatible with an eosinophilic granuloma.
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