Eruptive squamous atypia
Alerts and Notices
Synopsis
ESA can be subcategorized into 2 morphologic types. The first type is focal koebnerizing ESA (FK-ESA), which appears as a hyperkeratotic papule or plaque that arises in areas of localized skin trauma, such as surgery, laser therapy, or tattoo application. The second type is diffuse ESA (D-ESA), which presents as multifocal ESA lesions, often on the arms or legs.
Both patterns may occur simultaneously. A skin biopsy should be used to confirm the diagnosis.
Codes
ICD10CM:L85.8 – Other specified epidermal thickening
SNOMEDCT:
69740004 – Squamous cell atypia
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Squamous cell carcinoma (SCC)
- Solitary KA
- Prurigo nodularis
- Generalized eruptive KA of Grzybowski – Thousands of skin papules may appear with mucous membrane involvement
- Multiple self-healing squamous epithelioma (Ferguson-Smith disease) – Multiple and spontaneously regressing KAs, usually begin in the third decade of life in sun-exposed skin areas
- Pemphigoid nodularis
- Foreign body reaction
Best Tests
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:02/13/2022
Last Updated:02/16/2022
Last Updated:02/16/2022