Eruptive xanthoma
Alerts and Notices
Synopsis
The skin lesions usually resolve within 6 months with appropriate treatment.
Codes
ICD10CM:E78.2 – Mixed hyperlipidemia
SNOMEDCT:
238952003 – Eruptive xanthoma
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Granuloma annulare – Skin-colored to reddish-brown papules, often forming annular plaques.
- Xanthoma disseminatum should be considered in children; presents with brown to yellow papillary rash on flexor surfaces and often on the eyelids.
- Folliculitis – Follicularly based erythematous papules and pustules.
- Pityrosporum folliculitis – Folliculocentric and often pruritic.
- Steroid acne – Predilection for chest and back, often 2-5 weeks after starting oral steroids.
- Sarcoidosis – May also affect extensor extremities but typically red-brown in color.
- Leukemia cutis – Firm, deep red-brown / plum colored.
- Langerhans cell histiocytosis – Predilection for skin folds.
- Multicentric reticulohistiocytosis – Distribution typically along acral areas (head, hands [especially periungual], and juxta-articular regions of extremities).
- Lichen amyloidosis – Often with rippled appearance.
- Erythema elevatum diutinum – Nodules and plaques over extensor extremities.
Best Tests
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:06/06/2018
Last Updated:07/01/2018
Last Updated:07/01/2018
Eruptive xanthoma