Erythema annulare centrifugum in Infant/Neonate
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Synopsis

Erythema annulare centrifugum (EAC) is characterized by circular or polycyclic lesions that may be superficial or deep. Individual lesions enlarge over days to months and subsequently resolve, but new lesions may continue to develop for weeks to years. They may be anywhere on the body, and usually several are present at once. EAC can occur at any age but tends to affect young or middle-aged adults. There is no sex or racial predilection.
Some believe there is an association with underlying infection (fungal, yeast, Pseudomonas aeruginosa, poxvirus, Epstein-Barr virus, mycobacteria, ascariasis), medications, malignancy (leukemia, Hodgkin lymphoma), blue cheese ingestion, or collagen vascular diseases.
Some believe there is an association with underlying infection (fungal, yeast, Pseudomonas aeruginosa, poxvirus, Epstein-Barr virus, mycobacteria, ascariasis), medications, malignancy (leukemia, Hodgkin lymphoma), blue cheese ingestion, or collagen vascular diseases.
Codes
ICD10CM:
L53.1 – Erythema annulare centrifugum
SNOMEDCT:
399914006 – Erythema annulare centrifugum
L53.1 – Erythema annulare centrifugum
SNOMEDCT:
399914006 – Erythema annulare centrifugum
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
Superficial lesions may be confused with:
Other considerations:
Other considerations:
- Erythema gyratum repens (faster moving)
- Erythema migrans (marker of Lyme disease)
- Annular urticaria
- Urticaria multiforme
- Urticarial phase of bullous pemphigoid
- Erythema multiforme
- Erythema marginatum (rheumatic fever)
- Necrolytic migratory erythema (associated with glucagonomas)
- Psoriasis
- Tumid lupus erythematosus
- Granuloma annulare
- Sarcoidosis
- Mycosis fungoides
Best Tests
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.
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References
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Last Reviewed:02/21/2018
Last Updated:09/30/2019
Last Updated:09/30/2019