ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferencesView all Images (36)
Erythema elevatum diutinum
Print
Other Resources UpToDate PubMed

Erythema elevatum diutinum

Print Images (36)
Contributors: Altaaf Parker MBChB, FCDerm, Anisa Mosam MBChB, MMed, FCDerm, PhD, Ncoza C. Dlova MBChB, FCDerm, PhD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Erythema elevatum diutinum (EED) is a rare form of leukocytoclastic vasculitis in which immune complexes are deposited in small blood vessels, leading to inflammation. The exact etiology is unknown, but inciting factors may include infectious agents (streptococci, human immunodeficiency virus [HIV]), hematologic malignancies (monoclonal gammopathies), inflammatory bowel disease, celiac sprue, and rheumatologic disorders. EED may also be seen in association with immunoglobulin A (IgA) paraproteinemia. Case reports document associations with interferon-b, antituberculosis drugs, cisplatin, and erythropoietin.

Erythema elevatum diutinum presents as violaceous, erythematous, or brown papules, nodules, and/or plaques, predominantly over the extensor surfaces of the body. The most common associated symptom is arthralgia, although the lesions themselves may be painful or pruritic. Sometimes ocular abnormalities such as peripheral keratitis, panuveitis, and nodular scleritis have been seen. There is no racial predilection, but there is a slight female preponderance of disease. Incidence is highest in middle-aged to older adults, but may present earlier in those with HIV infection.

Codes

ICD10CM:
L95.1 – Erythema elevatum diutinum

SNOMEDCT:
58872001 – Erythema elevatum diutinum

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required

References

Subscription Required

Last Reviewed: 10/02/2017
Last Updated: 10/11/2017
Copyright © 2019 VisualDx®. All rights reserved.
Erythema elevatum diutinum
Print 36 Images Filter Images
View all Images (36)
(with subscription)
 Reset
Erythema elevatum diutinum : Buttocks, Erythema, Extensor distribution, Painful skin lesions, Arthralgia, Smooth papules, Smooth nodules, Smooth plaques, Knees
Clinical image of Erythema elevatum diutinum
Copyright © 2019 VisualDx®. All rights reserved.