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Erythema marginatum in Infant/Neonate
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Erythema marginatum in Infant/Neonate

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Contributors: Christopher Iriarte MD, Susan Burgin MD
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Synopsis

Erythema marginatum : Erythema, Thigh, Trunk, Upper arm, Blanching patch
Erythema marginatum is a distinctive reactive annular erythema most commonly associated with acute rheumatic fever secondary to streptococcal infection. It is typically found on the trunk and proximal extremities. It usually follows the onset of migratory arthritis, but it may occur months after carditis. Erythema marginatum is typically nonpruritic and overall asymptomatic. Approximately 10% of patients with acute rheumatic fever have the associated rash of erythema marginatum. It is observed more frequently in children than in adults. Erythema marginatum is one of the major Jones criteria, the set of criteria used to diagnose acute rheumatic fever.

Rarer conditions that have been associated with erythema marginatum include psittacosis and C1 esterase inhibitor deficiency (also known as hereditary angioedema). Of note, a case of hemorrhagic erythema marginatum was reported as a cutaneous toxicity to sorafenib in a patient undergoing treatment for hepatocellular carcinoma.

Codes

ICD10CM:
L53.2 – Erythema marginatum

SNOMEDCT:
50610002 – Erythema marginatum

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed:10/13/2020
Last Updated:10/13/2020
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Erythema marginatum in Infant/Neonate
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A medical illustration showing key findings of Erythema marginatum : Erythema, Thigh, Trunk, Upper arm, Blanching patch
Clinical image of Erythema marginatum - imageId=1120099. Click to open in gallery. caption: 'A close-up of annular and gyrate erythematous plaques with faint surrounding pink-orange patches.'
A close-up of annular and gyrate erythematous plaques with faint surrounding pink-orange patches.

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