ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferencesView all Images (16)
Erythromelalgia in Adult
See also in: Cellulitis DDx
Print
Other Resources UpToDate PubMed

Erythromelalgia in Adult

See also in: Cellulitis DDx
Print Images (16)
Contributors: Tara Mahar MD, Art Papier MD
Other Resources UpToDate PubMed

Synopsis

Erythromelalgia refers to a rare disease process in which there is warmth, redness, and burning pain of the extremities. It may be idiopathic or secondary to an underlying disorder such as an autoimmune or myeloproliferative disease. Although the pathophysiology of erythromelalgia has not been fully elucidated, its secondary forms are associated with thrombocythemia with resultant platelet thrombi. In cases of idiopathic erythromelalgia, possible contributing factors may be aberrations in skin perfusion or nerve hypersensitivity and/or dysfunction.

Erythromelalgia occurs most commonly on the feet, but the hands, face, and ears may be affected. It is usually bilateral, and patients may experience symptoms constantly or intermittently. These symptoms are exacerbated by heat and relieved by immersion in cold water. A gene on the long arm of chromosome 2 has been linked to cases of idiopathic erythromelalgia.

Erythromelalgia should be distinguished from cellulitis on the basis of location and burning paresthesias. It is usually bilateral.

For more information, see OMIM.

Codes

ICD10CM:
I73.81 – Erythromelalgia

SNOMEDCT:
37151006 – Erythromelalgia

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required

References

Subscription Required

Last Updated: 12/29/2017
Copyright © 2019 VisualDx®. All rights reserved.
Erythromelalgia in Adult
See also in: Cellulitis DDx
Print 16 Images Filter Images
View all Images (16)
(with subscription)
 Reset
Erythromelalgia : Bilateral, Burning skin sensation, Erythema, Skin warm to touch, Blanching patch, Paresthesias, Feet, Hands
Clinical image of Erythromelalgia
Copyright © 2019 VisualDx®. All rights reserved.