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Ewing sarcoma in Adult
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Ewing sarcoma in Adult

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Contributors: Benjamin L. Mazer MD, MBA, Carla Casulo MD
Other Resources UpToDate PubMed


Ewing sarcoma is a small, round, blue cell tumor that primarily affects bone and soft tissue. It is often metastatic and has been found in a variety of organs. It typically presents with bone or soft tissue pain. Ewing sarcoma most commonly affects adolescent males. It is considered a poorly-differentiated malignancy on the primitive neuroectodermal tumor (PNET) spectrum. Ewing sarcoma is categorized as a "small round blue cell tumor" due to its histologic appearance, which it shares with other types of malignancies. Ewing sarcomas may be differentiated from these other tumors by CD99 positivity, presence of rosettes on microscopy, and a t(11;22) translocation, which nearly all Ewing sarcomas contain.

Treatment consists of systemic chemotherapy and surgical excision of the primary tumor. Radiotherapy is also sometimes utilized. Prognosis depends on multiple factors, but Ewing sarcoma can be curable even when metastatic.


C41.9 – Malignant neoplasm of bone and articular cartilage, unspecified

76909002 – Ewing's sarcoma

Differential Diagnosis & Pitfalls

Possibilities include:
Each has different appearance on diagnostic imaging.

Best Tests

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Last Updated: 08/18/2016
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Ewing sarcoma in Adult
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Ewing sarcoma : Bone pain, Developed steadily , Soft tissue swelling, Limited range of motion
Imaging Studies image of Ewing sarcoma
Axial T1 MRI sequence demonstrates an infiltrative low/intermediate T1 signal mass involving the left iliac bone with cortical destruction, and an associated soft tissue mass extending into the gluteal and iliacus musculature (with small areas of hemorrhagic necrosis). Biopsy of this mass showed Ewing sarcoma.
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