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Exanthematous drug eruption in Adult
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Exanthematous drug eruption in Adult

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Contributors: Philip I. Song MD, Susan Burgin MD
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Synopsis

Exanthematous drug eruption (EDE; also known as morbilliform drug eruption) is the most common of all medication-induced drug rashes. It consists of red macules and papules that often arise on the trunk and spread symmetrically to involve the proximal extremities. In severe cases, lesions coalesce and may lead to erythroderma. Palms, soles, and mucous membranes may also be involved. Pruritus is a common complaint. While most patients are afebrile, a low-grade fever may occur in more severe reactions. Onset is usually within 7-10 days of initiating a medication, but a lag time of up to 14 days has been reported. The eruption may occur even if the offending medication has already been discontinued.

EDE is most commonly seen with the use of antibiotics (penicillins and sulfas), allopurinol, phenytoin, barbiturates, chlorpromazine, carbamazepine, gold, d-penicillamine, captopril, naproxen, and piroxicam, but many other drug culprits have been reported, including chemotherapeutic, biologic, and immunotherapeutic (checkpoint inhibitor) agents.

Codes

ICD10CM:
L27.0 – Generalized skin eruption due to drugs and medicaments taken internally

SNOMEDCT:
238814003 – Maculopapular drug eruption

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 04/10/2017
Last Updated: 05/30/2017
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Exanthematous drug eruption in Adult
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Exanthematous drug eruption : Rash, Reaction 0 to 5 days after drug, Reaction 6 to 30 days after drug, Widespread, Pruritus
Clinical image of Exanthematous drug eruption
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