Fibrous papule of nose - Skin
Their exact etiology is unknown, but some have suggested that fibrous papules represent nevi that no longer synthesize S-100 protein. However, other studies involving electron microscopy suggest that they are derived from fibroblasts, because premelanosomes and basal lamina are not seen.
There is no known predilection for a particular sex, ethnicity, or socioeconomic status. The papules typically occur in middle age.
Patients with multiple fibrous papules should be examined for other signs of systemic diseases including tuberous sclerosis, neurofibromatosis type 2, multiple endocrine neoplasia type 1, and Hornstein-Knickenberg syndrome.
Pediatric Patient Considerations:
Tuberous sclerosis should be considered in children with multiple fibrous papules. Inquire about medical and family history including seizures, mental impairment or developmental delay, behavioral disorders, visual problems, and tumors of the brain, heart, kidneys, lungs, and skin.
D23.39 – Other benign neoplasm of skin of other parts of face
254745007 – Fibrous papule of nose
- Basal cell carcinoma – Look for a pearly papule with telangiectasias, erosion, or ulceration. Ask about increases in size, bleeding, or ulceration. Shave biopsy if this is suspected.
- Compound nevus – Presents as a round, flesh-colored papule; usually present for many years without associated changes.
- Sebaceous hyperplasia – Presents as a flesh-colored to yellow papule with a central pore; frequently located on the forehead.
- Common wart
- Cherry hemangioma – Presents as a cherry red, round papule, usually on the trunk but may occur on the head, neck, and extremities.
- Lobular capillary hemangioma (pyogenic granuloma) – Presents as a fungating mass that bleeds excessively when traumatized; more common in children.
- Adnexal tumor – May present as a nonspecific flesh-colored papule.