Fixed drug eruption - Anogenital in
See also in: Overview,Cellulitis DDx,Oral Mucosal LesionAlerts and Notices
Synopsis

Fixed drug eruption (FDE) is a cutaneous adverse drug reaction that recurs at the same body site each time the individual is re-exposed to the culprit drug. One or more sharply demarcated, red or violaceous patches that are typically round develop within minutes to hours of exposure to the inciting drug. These may vary from 0.5 to several centimeters in size. They are usually asymptomatic, although burning, pain, or pruritus may occur.
While any cutaneous surface may be affected, the oral and anogenital mucosa are most frequently involved. In the anogenital region in men, the patches of FDE most commonly affect the glans penis. Additional possible sites of involvement include the prepuce, coronal sulcus, shaft of the penis, and scrotum. Bullous FDE more frequently involves the genital region in men.
FDE is most commonly solitary, but some individuals may develop multiple patches. There may be an increasing number of patches seen with each exposure. Healing with postinflammatory hyperpigmentation is common.
Numerous drugs have been implicated in causing FDE. The most commonly associated drug classes for FDE in the anogenital region are also the most frequently seen culprit medications for FDE in general. These medication classes include antibiotics, in particular sulfonamides, trimethoprim, and tetracyclines, and NSAIDs, including naproxen, ibuprofen, and celecoxib. Other drugs implicated in FDE include amoxicillin, erythromycin, metronidazole, fluconazole, paracetamol (acetaminophen), cetirizine, hydroxyzine, methylphenidate, oral contraceptives, quinine, and phenolphthalein. Biologic agents including ustekinumab, adalimumab, and abatacept have been reported to cause fixed drug eruptions. A nonpigmenting variant is seen with pseudoephedrine.
While any cutaneous surface may be affected, the oral and anogenital mucosa are most frequently involved. In the anogenital region in men, the patches of FDE most commonly affect the glans penis. Additional possible sites of involvement include the prepuce, coronal sulcus, shaft of the penis, and scrotum. Bullous FDE more frequently involves the genital region in men.
FDE is most commonly solitary, but some individuals may develop multiple patches. There may be an increasing number of patches seen with each exposure. Healing with postinflammatory hyperpigmentation is common.
Numerous drugs have been implicated in causing FDE. The most commonly associated drug classes for FDE in the anogenital region are also the most frequently seen culprit medications for FDE in general. These medication classes include antibiotics, in particular sulfonamides, trimethoprim, and tetracyclines, and NSAIDs, including naproxen, ibuprofen, and celecoxib. Other drugs implicated in FDE include amoxicillin, erythromycin, metronidazole, fluconazole, paracetamol (acetaminophen), cetirizine, hydroxyzine, methylphenidate, oral contraceptives, quinine, and phenolphthalein. Biologic agents including ustekinumab, adalimumab, and abatacept have been reported to cause fixed drug eruptions. A nonpigmenting variant is seen with pseudoephedrine.
Codes
ICD10CM:
L27.1 – Localized skin eruption due to drugs and medicaments taken internally
SNOMEDCT:
73692007 – Fixed drug eruption
L27.1 – Localized skin eruption due to drugs and medicaments taken internally
SNOMEDCT:
73692007 – Fixed drug eruption
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Lichen planus
- Tinea cruris
- Recurrent herpes simplex virus infection
- Red scrotum syndrome
- Primary syphilis
- Erythema multiforme
- Reactive infectious mucocutaneous eruption (RIME)
- Contact dermatitis
- Cellulitis or erysipelas
- Stevens-Johnson syndrome / toxic epidermal necrolysis
- Postinflammatory pigmentation
Best Tests
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.
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References
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Last Reviewed:02/02/2021
Last Updated:02/16/2022
Last Updated:02/16/2022

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Fixed drug eruption - Anogenital in
See also in: Overview,Cellulitis DDx,Oral Mucosal Lesion