Fixed drug eruption - Anogenital in
While any cutaneous surface may be affected, the oral and anogenital mucosa are most frequently involved. In the anogenital region in men, the patches of FDE most commonly affect the glans penis. Additional possible sites of involvement include the prepuce, coronal sulcus, shaft of the penis, and scrotum. Bullous FDE more frequently involves the genital region in men.
FDE is most commonly solitary, but some individuals may develop multiple patches. There may be an increasing number of patches seen with each exposure. Healing with postinflammatory hyperpigmentation is common.
Numerous drugs have been implicated in causing FDE. The most commonly associated drug classes for FDE in the anogenital region are also the most frequently seen culprit medications for FDE in general. These medication classes include antibiotics, in particular sulfonamides, trimethoprim, and tetracyclines, and NSAIDs, including naproxen, ibuprofen, and celecoxib. Other drugs implicated in FDE include amoxicillin, erythromycin, metronidazole, fluconazole, paracetamol (acetaminophen), cetirizine, hydroxyzine, methylphenidate, oral contraceptives, quinine, and phenolphthalein. Biologic agents including ustekinumab, adalimumab, and abatacept have been reported to cause fixed drug eruptions. A nonpigmenting variant is seen with pseudoephedrine.
L27.1 – Localized skin eruption due to drugs and medicaments taken internally
73692007 – Fixed drug eruption
- Lichen planus
- Tinea cruris
- Recurrent herpes simplex virus infection
- Red scrotum syndrome
- Primary syphilis
- Erythema multiforme
- Reactive infectious mucocutaneous eruption (RIME)
- Contact dermatitis
- Cellulitis or erysipelas
- Stevens-Johnson syndrome / toxic epidermal necrolysis
- Postinflammatory pigmentation