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Focal segmental glomerulosclerosis
Other Resources UpToDate PubMed

Focal segmental glomerulosclerosis

Contributors: Catherine Moore MD
Other Resources UpToDate PubMed

Synopsis

Focal segmental glomerulosclerosis (FSGS) is a histologic description of a glomerular lesion that is associated with significant proteinuria and the nephrotic syndrome. This pathologic finding can be the result of systemic disorders (termed "secondary" causes of FSGS) or may represent primary disease.

Primary FSGS is itself a heterogeneous disease, likely with multiple pathogenic mechanisms resulting in a similar histologic pattern of injury. Secondary causes include chronic reflux nephropathy, chronic hypertension, and obesity.

Clinical presentations vary widely, but typically individuals with primary FSGS present with the nephrotic syndrome. Secondary FSGS is typically associated with less severe proteinuria, often without hypoalbuminemia or peripheral edema. Patients may require renal transplantation, which may have a high frequency of failure from recurrence of FSGS.

For more information, see OMIM.

Codes

ICD10CM:
N26.9 – Renal sclerosis, unspecified

SNOMEDCT:
236403004 – Focal Segmental Glomerulosclerosis

Differential Diagnosis & Pitfalls

Differential diagnosis of nephrotic range proteinuria:

Best Tests

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated:04/25/2018
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Focal segmental glomerulosclerosis
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Focal segmental glomerulosclerosis : Microscopic hematuria, Proteinuria, Peripheral leg edema, Generalized edema, Weight gain, BP increased
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