Contents

SynopsisCodesDifferential Diagnosis & PitfallsBest TestsDrug Reaction DataReferences
Focal segmental glomerulosclerosis
Other Resources UpToDate PubMed

Focal segmental glomerulosclerosis

Contributors: Catherine Moore MD
Other Resources UpToDate PubMed

Synopsis

Focal segmental glomerulosclerosis (FSGS) is a histologic description of a glomerular lesion that is associated with significant proteinuria and the nephrotic syndrome. This pathologic finding can be the result of systemic disorders (termed "secondary" causes of FSGS) or may represent primary disease.

Primary FSGS is itself a heterogeneous disease, likely with multiple pathogenic mechanisms resulting in a similar histologic pattern of injury. Secondary causes include chronic reflux nephropathy, chronic hypertension, and obesity.

Clinical presentations vary widely, but typically individuals with primary FSGS present with the nephrotic syndrome. Secondary FSGS is typically associated with less severe proteinuria, often without hypoalbuminemia or peripheral edema. Patients may require renal transplantation, which may have a high frequency of failure from recurrence of FSGS. An early trial of the small-molecule drug inaxaplin significantly reduced proteinuria for patients with apolipoprotein L1 (APOL1) risk variants G1 and G2, which commonly occur in people descended from sub-Saharan Africa. Studies are ongoing.

Codes

ICD10CM:
N26.9 – Renal sclerosis, unspecified

SNOMEDCT:
236403004 – Focal Segmental Glomerulosclerosis

Differential Diagnosis & Pitfalls

Subscription Required

Best Tests

Subscription Required

Drug Reaction Data

Subscription Required

References

Subscription Required

Last Updated:03/27/2023
Copyright © 2024 VisualDx®. All rights reserved.
Focal segmental glomerulosclerosis
Print  
A medical illustration showing key findings of Focal segmental glomerulosclerosis : Microscopic hematuria, Proteinuria, Peripheral leg edema, Generalized edema, Weight gain, BP increased
Copyright © 2024 VisualDx®. All rights reserved.