Fordyce spots are normal, ectopic, large, superficial sebaceous glands not associated with hair follicles. The "spots" are asymptomatic and are found most commonly on the vermillion of the lips and on the inferior eyelids. They can also be found on the genitals, including the labia majora and minora in females and the glans penis, penile shaft, and the mucosal aspect of the foreskin in males. The spots are usually clustered and asymptomatic.

The likelihood of developing Fordyce spots increases with age; however, these small papules can be seen in patients of any age. Their development can be associated with hormonal changes, and puberty can bring about their onset. 

Patients may experience itching or irritation if they have been treating the papules inappropriately.