Fox-Fordyce disease
See also in: AnogenitalAlerts and Notices
Synopsis

Fox-Fordyce disease is a rare inflammatory condition of apocrine gland-bearing regions caused by obliteration of the follicular infundibulum with keratin. The etiology is unknown, although an endocrine role has been postulated. The disease manifests as intensely pruritic, skin-colored or keratotic papules in the axillary, anogenital, umbilical, and periareolar areas. Heat, humidity, stress, and other external stimuli such as laser hair removal may worsen symptoms and lead to appearance of new papules.
It is most common in females between puberty and age 35. Less commonly, it can affect male patients, prepubescent girls, and postmenopausal women. It may flare perimenstrually and improve during pregnancy and after menopause.
It is most common in females between puberty and age 35. Less commonly, it can affect male patients, prepubescent girls, and postmenopausal women. It may flare perimenstrually and improve during pregnancy and after menopause.
Codes
ICD10CM:
L75.2 – Apocrine miliaria
SNOMEDCT:
65038009 – Fox-Fordyce disease
L75.2 – Apocrine miliaria
SNOMEDCT:
65038009 – Fox-Fordyce disease
Look For
Subscription Required
Diagnostic Pearls
Subscription Required
Differential Diagnosis & Pitfalls
Best Tests
Subscription Required
Management Pearls
Subscription Required
Therapy
Subscription Required
Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.
Subscription Required
References
Subscription Required
Last Reviewed:01/31/2021
Last Updated:02/01/2021
Last Updated:02/01/2021

Premium Feature
VisualDx Patient Handouts
Available in the Elite package
- Improve treatment compliance
- Reduce after-hours questions
- Increase patient engagement and satisfaction
- Written in clear, easy-to-understand language. No confusing jargon.
- Available in English and Spanish
- Print out or email directly to your patient
Upgrade Today
Fox-Fordyce disease
See also in: Anogenital