Approximately 25% of initial identifications will be associated with a molar pregnancy. It is more common after having a complete, versus partial, mole. About 50% of cases will follow full-term pregnancies. Risk factors include increased age at time of pregnancy and history of a prior molar pregnancy. Incidence is approximately 1 in 40 000 pregnancies in North America and Europe.
Most cases are identified by an abnormally trending beta-human chorionic gonadotrophin (bhCG) curve following evacuation of a molar pregnancy or by the patient having abnormal postpartum bleeding. In some cases, pathologic evaluation of evacuated molar pregnancy tissue or postdelivery placenta will identify choriocarcinoma.
C58 – Malignant neoplasm of placenta
417570003 – Gestational choriocarcinoma
Differential Diagnosis & Pitfalls