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Giant cell fibroblastoma
Other Resources UpToDate PubMed

Giant cell fibroblastoma

Contributors: Mack Su, Susan Burgin MD
Other Resources UpToDate PubMed


Giant cell fibroblastoma (GCF) is a rare tumor considered to be a variant of dermatofibrosarcoma protuberans (DFSP) with similar clinical behavior and molecular features. It is a slow-growing tumor most commonly found on the trunk and proximal extremities. It is not known to metastasize but can be locally aggressive and has a high rate of local recurrence. GCF harbors the same t(17;22) chromosomal translocation as DFSP that places the platelet-derived growth factor beta chain gene (PDGFB) under control of the collagen type I alpha 1 gene (COL1A1) promoter. Hybrid lesions may occur containing features of both GCF and DFSP. In addition, cases of GCF recurring as DFSP and vice versa have been reported in the literature.

GCF notably differs from DFSP in patient demographics and histologic features (see Best Tests section). GCF predominantly occurs in infants and children younger than 5 years, with a strong predilection for males.


C44.90 – Unspecified malignant neoplasm of skin, unspecified

128742004 – Giant cell fibroblastoma

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Dermatofibrosarcoma protuberans – Typically presents later in life with different histologic features.
  • Fibrous hamartoma of infancy – Distinct histology demonstrates fibroblasts, mesenchymal tissue, and mature fat.
  • Keloid – History of injury.
  • Hypertrophic scar
  • Dermatofibroma
  • Fibrosarcoma
  • Infantile fibrosarcoma
  • Liposarcoma
  • Nodular fasciitis
  • Cutaneous dermoid cyst
  • Epidermoid cyst

Best Tests

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Management Pearls

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Last Updated:01/16/2022
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Giant cell fibroblastoma
A medical illustration showing key findings of Giant cell fibroblastoma
Copyright © 2024 VisualDx®. All rights reserved.