Giant cell tumor of bone
GCT of bone is characterized by localized pain, swelling, and limited range of motion.
Management traditionally relied on curettage and bone graft, but recurrence was as high as 50%. Improved aggressive curettage, high-speed burring, and use of adjuvants and bone cement have lowered the rate of recurrence. Various types of targeted therapies, surgery, radiation therapy, and chemotherapy are in use.
D48.0 – Neoplasm of uncertain behavior of bone and articular cartilage
697970009 – Giant cell tumor of bone
Differential Diagnosis & Pitfalls
- Brown cell tumor of hypoparathyroidism – Histologically very similar to GCT. Blood studies consistent with hypoparathyroidism can help differentiate these.
- Aneurysmal bone cyst – May coexist with GCT.
- Telangiectatic osteosarcoma
- Chondroblastoma – Seen in the epiphyseal region of skeletally immature patients.
- Nonossifying fibroma – Usually in younger age range.
- Chondrosarcoma – Seen in older ages.
- Chondromyxoid fibroma – Seen in the metaphyseal region with a defined sclerotic margin.