Giant papillary conjunctivitis (GPC), a severe form of contact-lens–induced conjunctivitis, is an inflammatory response to contact lens solutions, the contact lens material, protein deposits on the contact lenses, or mechanical trauma. Most likely, the mechanism is multifactorial in nature. Patients have a tendency to complain about red eyes, mucous discharge, and ocular irritation and itching. In more severe cases, contact lens wear may be uncomfortable or impossible and be associated with ptosis of the eyelids. The conjunctivitis tends to be bilateral but can be asymmetric in presentation. While most patients are contact lenses wearers, chronic irritation from an exposed corneal suture can give similar signs and symptoms. Patients predisposed to ocular allergy or dry eye may be more prone to develop contact-lens–induced conjunctivitis.