Glomeruloid hemangiomas (GH) are acquired reactive vascular lesions of the skin and other tissues. They present most commonly on the trunk and extremities, but lesions on the head and neck and in extracutaneous tissues such as the uterus have been described.

Previously, GH were believed to be found only in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, multiple myeloma, and skin changes and sclerotic bone changes) syndrome. Increased serum vascular endothelial growth factor (VEGF) levels are found in almost all patients with POEMS syndrome, and this is thought to play a role in the pathogenesis of GH. However, cases of patients with GH but without POEMS syndrome have been reported. This remains somewhat controversial as it is not known whether GH can occur in otherwise healthy individuals, if the cases in the literature describe patients who later displayed more of the findings of POEMS syndrome, or if the vascular lesions described were actually papillary hemangiomas, which can be challenging to distinguish from GH.

There also have been a small number of reports describing GH in the setting of Crow-Fukase syndrome and TAFRO (thrombocytopenia, anasarca, fever, renal dysfunction, and organomegaly) syndrome.