Gorham disease (Gorham-Stout syndrome) is a rare disease marked by generally painless, progressive bone loss. Associated with proliferation of lymphatic vessels and substantial osteoclast activation. Etiology is unknown. May affect one or many bones and even spread to soft tissue. Locations frequently involved are the ribs, jaw, spine, skull, clavicle, and pelvis. Common findings include bone pain, tissue swelling, joint contractures, pathologic fracture, and decreased range of motion. Severe cases can cause deformity or disability, and may be life-threatening.

Treatment is symptomatic and may include surgical resection.