After an incubation period of days to months, subcutaneous nodules develop at inoculation sites that later erode. The lesions are usually painless, but in atypical variants of the disease, there may be mild pain. Autoinoculation is a common feature, producing so-called "kissing lesions" on adjacent skin and, less commonly, extending to underlying abdominal organs. Subcutaneous granulomas occur in the inguinal area that mimic lymphadenopathy (so-called pseudo-buboes). Without treatment, chronic lesions can result in lymphatic obstruction leading to genital lymphedema and distortion. Extragenital lesions, including oral, bone, and abdominal organs, are reported in 6% of cases. Constitutional symptoms are notably absent.
In rare cases, squamous cell carcinoma may develop in chronically present ulcers.
Granuloma inguinale predisposes individuals to transmission of human immunodeficiency virus (HIV).
A58 – Granuloma inguinale
28867007 – Granuloma inguinale
- Cellulitis / superinfected traumatic erosions
- Lymphogranuloma venereum
- Syphilis – Condyloma lata
- Tuberculous chancre
- Condyloma acuminata
- Buschke-Lowenstein tumor
- Fournier or gas gangrene
- Herpes simplex virus (HSV)
- Behçet syndrome
- Pyoderma gangrenosum
- Tumors – Squamous cell carcinoma, basal cell carcinoma, melanoma
- Ecthyma gangrenosum
- Crohn disease – May have concurrent genital edema and/or ulceration