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Herpes simplex virus in Infant/Neonate
See also in: Cellulitis DDx,Anogenital
Other Resources UpToDate PubMed

Herpes simplex virus in Infant/Neonate

See also in: Cellulitis DDx,Anogenital
Contributors: Susan Burgin MD, Eric Ingerowski MD, FAAP, Belinda Tan MD, PhD, Craig N. Burkhart MD, Dean Morrell MD
Other Resources UpToDate PubMed

Synopsis

Herpes simplex virus (HSV) infection in the infant typically occurs when the virus is acquired from caregivers, family members, or other children. Those with preexisting dermatitis can be predisposed to infection.

Characteristic skin lesions are vesicles, pustules, crusts, or erosions. Rarely there can be coinfection of the skin with Staphylococcal aureus and HSV together.

Other symptoms of primary HSV infection in an infant include feeding problems, fever, and/or lethargy. In infants with atopic dermatitis, HSV can spread widely (eczema herpeticum).

See neonatal herpes for discussion of perinatal infection.

Codes

ICD10CM:
B00.1 – Herpesviral vesicular dermatitis

SNOMEDCT:
88594005 – Herpes simplex

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Acropustulosis of infancy
  • Congenital self-healing histiocytosis
  • Molluscum contagiosum – Lesions are usually not painful, are slow to evolve, and are rarely grouped.
  • Bullous impetigo
  • Fixed drug eruption
  • Diaper dermatitis candidiasis
  • Varicella
  • Herpes zoster
  • Hand, foot, and mouth disease
  • Contact dermatitis, Allergic contact dermatitis or Diaper irritant contact dermatitis

Best Tests

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Management Pearls

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Therapy

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References

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Last Reviewed:01/28/2023
Last Updated:02/01/2023
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Patient Information for Herpes simplex virus in Infant/Neonate
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Herpes simplex virus in Infant/Neonate
See also in: Cellulitis DDx,Anogenital
A medical illustration showing key findings of Herpes simplex virus : Grouped configuration, Recurring episodes or relapses, Umbilicated vesicle
Clinical image of Herpes simplex virus - imageId=111180. Click to open in gallery.  caption: 'A close-up of grouped cloudy vesicles on an erythematous base.'
A close-up of grouped cloudy vesicles on an erythematous base.
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