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Human polyomavirus 9 infection
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Human polyomavirus 9 infection

Contributors: Asha Nanda, Jourdan Brandon, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Human polyomavirus 9 (HPyV9) is a polyomavirus with up to 30% seroprevalence in solid organ transplant recipients (SOTRs). Despite its significant seroprevalence in this population, it had previously not been associated with disease. However, in 2022, sentinel literature described a hyperkeratotic papular eruption followed by pulmonary compromise, clinical decline, and death in SOTRs from HPyV9 infection. Patients were 7-13 years out from their transplants (kidneys or lung), and 2 of the 3 had a history of more than 1 transplant (3 kidney transplants in 1 patient and 2 lung transplants in another). Each patient developed an acral eruption that generalized and was followed by the development of systemic symptoms, including anorexia, weight loss, fatigue, dyspnea, and ultimate demise 4-13 months after rash onset. Acute lung injury from diffuse alveolar hemorrhage was thought to be the cause of death in the reported patients.

Codes

ICD10CM:
B33.8 – Other specified viral diseases

SNOMEDCT:
5714002 – Disease caused by Polyomavirus

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Last Reviewed:06/21/2022
Last Updated:06/22/2022
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Human polyomavirus 9 infection
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A medical illustration showing key findings of Human polyomavirus 9 infection : Acral distribution, Malaise, Anorexia, Dyspnea
Copyright © 2022 VisualDx®. All rights reserved.