Most often, symptoms peak between 7-14 weeks of gestation and then usually resolve thereafter, although they could continue to be an issue throughout the pregnancy.
Risk factors include multiple gestation, personal or family history of hyperemesis, molar pregnancy, and having a female fetus.
Diagnosis is one of exclusion of other potential causes of nausea / vomiting. Although there are no specific criteria, patients with hyperemesis usually have perceptible weight loss (approximately 5% of prepregnancy weight), ketonuria, and persistent nausea / vomiting. Some patients will have electrolyte imbalance as well.
Hyperemesis is the most common cause for hospitalization in the first trimester of pregnancy.
Some studies have suggested that taking a multivitamin at the time of conception may help reduce the incidence of hyperemesis.
Related topic: Wernicke encephalopathy
O21.0 – Mild hyperemesis gravidarum
14094001 – Hyperemesis gravidarum
Differential Diagnosis & Pitfalls
- Regular nausea / vomiting of pregnancy – Same symptoms without the criteria for hyperemesis.
- Gastroesophageal reflux disease (GERD)
- Hepatobiliary issues – Abnormal liver function tests will be present.
- Pancreatitis – Hyperemesis usually does not have more than mild abdominal tenderness with palpation.
- Hyperthyroidism – Elevated thyroid tests will be present.