Other Resources UpToDate PubMed


Other Resources UpToDate PubMed


Hyperglycemia is a condition of elevated glucose in blood serum which may be associated with diabetes (insulin deficiency or resistance). Absence of insulin contributes to deterioration of pancreatic β (beta) cells while nutrients fail to absorb in muscle, liver, and fat cells. This causes glucose levels to rise unchecked, along with amino acids and fatty acids in the circulating blood, greater incidence of ketone production, and risk of ketosis and life-threatening diabetic ketoacidosis. In the setting of insulin resistance, insulin signaling within glucose recipient tissues is defective; therefore, hyperglycemia perseveres.

Nondiabetic causes of hyperglycemia include glucose infusion, nonfasting blood specimen, drug-induced reaction (beta blockers, diuretics, estrogen products, glucocorticoids, etc), and certain liver, pancreatic, endocrine, and blood disorders (acromegaly, Cushing syndrome, glucagonoma, pheochromocytoma, etc). Other causes include stress or trauma (brain injury, general anesthesia, infection, myocardial infarction, etc).

In newborns, hyperglycemia is more often related to parenteral (intravenous) glucose administration in a sick infant, rather than due to neonatal diabetes mellitus.

Hyperglycemia is commonly asymptomatic. With sustained hyperglycemia, symptoms including thirst and craving for water, fatigue, frequent urination, rapid breathing, and fruity breath (diabetic ketoacidosis).

Related topics: diabetes mellitus type 1, diabetes mellitus type 2, maturity-onset diabetes of the young (MODY)


R73.9 – Hyperglycemia, unspecified

80394007 – Hyperglycemia


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Last Updated:10/14/2020
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Hyperglycemia : Hyperglycemia, Polyuria, Polydipsia
Copyright © 2021 VisualDx®. All rights reserved.